Rh-Catalyzed Coupling of Acrylic/Benzoic Acids with α-Diazocarbonyl Compounds: An Alternative Route for α-Pyrones and Isocoumarins
Chao Hong, Shuling Yu, Zhanxiang Liu, Yuhong Zhang
Abstract
)-H activation and destructed the formation of carboxylic ester that is formed via a nucleophilic O-H insertion to metal carbenoid. The procedure featured mild reaction conditions and broad substrate scope, providing a straightforward approach to the synthesis of α-pyrones and isocoumarins without the transformation of carboxylic acids to the corresponding amides.
Topics & Concepts
ChemistryIsocoumarinsCatalysisCarbenoidNucleophileRhodiumSubstrate (aquarium)Benzoic acidOrganic chemistryCombinatorial chemistryOceanographyGeologyCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions