Throat Microbial Community Structure and Functional Changes in Postsurgery Laryngeal Carcinoma Patients
Chi‐Yao Hsueh, Hongli Gong, Ning Cong, Ji Sun, Hui‐Ching Lau, Yang Guo, Qiang Huang, Xiaohui Yuan, Ming Zhang, Lei Tao, Liang Zhou
Abstract
Laryngeal squamous cell carcinoma greatly impacts patients' lives, and noninvasive means of prognostic assessment are valuable in determining the effectiveness of laryngectomy. We set out to study the microbial structure changes in the throat before and after laryngectomy and found the gene functions of several throat bacteria to be associated with human cancer signaling pathways. Our findings may offer insights into the disease management of patients with laryngeal squamous cell carcinoma. We hope to provide a means of using molecular mechanisms to improve the prognosis of laryngeal cancer treatment and to facilitate relevant research.