Mo@ZIF-8 nanozyme preparation and its antibacterial property evaluation
Zheng Lian, Chunqing Lu, Jiangqi Zhu, Xining Zhang, Ting Wu, Youlin Xiong, Zhiyi Sun, Rong Yang
Abstract
Types of nanozymes can produce free radicals and/or reactive oxygen species (ROS) to serve as broad spectrum antibacterial materials. Developing nanozyme-based antibacterial materials with good biocompatibility exhibits promising application prospects. In this study, we doped Mo to ZIF-8 (both components have good biocompatibility) to prepare a new nanozyme, Mo@ZIF-8, which can produce hydroxyl radicals (•OH) triggered by a low dosage of hydrogen peroxide (H 2 O 2 ), exhibiting effective antibacterial capability against both Gram-negative bacteria ( Escherichia coli ) and Gram-positive bacteria ( Staphylococcus aureus ). This work provides a reference for the design of antibacterial nanozymes with good biocompatibility.