Illuminating Non-genetic Cellular Heterogeneity with Imaging-Based Spatial Proteomics
Christian Gnann, Anthony J. Cesnik, Emma Lundberg
Abstract
Cellular heterogeneity is an important biological phenomenon observed across space and time in human tissues. Imaging-based spatial proteomic technologies can provide fruitful new readouts of phenotypic states for individual cells at subcellular resolution, which may help unravel the roles of non-genetic cellular heterogeneity in tumorigenesis and drug resistance.
Topics & Concepts
BiologyComputational biologyProteomicsPhenotypeGenetic heterogeneityGeneticsGeneSingle-cell and spatial transcriptomicsCell Image Analysis TechniquesAdvanced Proteomics Techniques and Applications