A sandwich-type surface-enhanced Raman scattering sensor using dual aptamers and gold nanoparticles for the detection of tumor extracellular vesicles
Min Hou, Dinggeng He, Hongchang Bu, Huizhen Wang, Jin Huang, Jinqing Gu, Ri Wu, Hung‐Wing Li, Xiaoxiao He, Kemin Wang
Abstract
A sandwich-type surface-enhanced Raman scattering (SERS) sensor using dual aptamers and gold-enhanced Raman signal probes has been successfully constructed for the detection of tumor-derived extracellular vesicles. The simple and sensitive sensor has the capability to detect tumor extracellular vesicles in 10-fold diluted human serum samples.
Topics & Concepts
AptamerRaman scatteringColloidal goldExtracellular vesiclesMaterials scienceRaman spectroscopyVesicleNanoparticleNanotechnologyChemistryOpticsMembraneMolecular biologyPhysicsBiochemistryCell biologyBiologyExtracellular vesicles in diseaseAdvanced biosensing and bioanalysis techniquesGold and Silver Nanoparticles Synthesis and Applications