Palladium-catalyzed chemoselective direct α-arylation of carbonyl compounds with chloroaryl triflates at the C–Cl site
Zicong Chen, Changxue Gu, On Ying Yuen, Chau Ming So
Abstract
Palladium-catalyzed chemoselective direct α-arylation of carbonyl compounds with chloroaryl triflates in the Ar–Cl bond is reported. The effects of –PR 2 and C2-alkyl groups of the ligands are investigated using experimental and computational methods.
Topics & Concepts
PalladiumCatalysisChemistryAlkylChemoselectivityCombinatorial chemistryMedicinal chemistryOrganic chemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsSulfur-Based Synthesis Techniques