Circular bivalent aptamers enhance the activation of the regenerative signaling pathway for repairing liver injury <i>in vivo</i>
Hong Liang, Zhike Yan, Yuhong Tong, Shan Chen, Jingying Li, Lanlan Chen, Huanghao Yang
Abstract
. The CBA showed enhanced biostability and receptor binding avidity, achieving effective pathway activation and satisfactory treatment in an acetaminophen-induced liver injury model. This work expands aptamer-based molecular engineering in regenerative medicine.
Topics & Concepts
AptamerBivalent (engine)In vivoAvidityRegenerative medicineCell biologyLiver injuryChemistryLiver regenerationReceptorSignal transductionBiophysicsRegeneration (biology)BiologyPharmacologyBiochemistryMolecular biologyStem cellImmunologyMetalAntibodyBiotechnologyOrganic chemistryAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryNanoplatforms for cancer theranostics