Synthesis and evaluation of multi-target-directed ligands with BACE-1 inhibitory and Nrf2 agonist activities as potential agents against Alzheimer’s disease
Lailiang Qu, Limei Ji, Cheng Wang, Heng Luo, Shang Li, Peng Wan, Fucheng Yin, Dehua Lu, Xingchen Liu, Lingyi Kong, Xiaobing Wang
Topics & Concepts
ChemistryGCLMGCLCAgonistOxidative stressPharmacologyActivator (genetics)BiochemistryIntracellularInhibitory postsynaptic potentialCell biologyReceptorGlutathioneInternal medicineEnzymeMedicineBiologyCholinesterase and Neurodegenerative DiseasesGenomics, phytochemicals, and oxidative stressOrganoselenium and organotellurium chemistry