Electrocatalytic C(sp<sup>3</sup>)–H/C(sp)–H cross-coupling in continuous flow through TEMPO/copper relay catalysis
Bin Guo, Hai‐Chao Xu
Abstract
)-H/C(sp)-H cross-coupling of tetrahydroisoquinolines with terminal alkynes has been achieved in a continuous-flow microreactor through 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO)/copper relay catalysis. The reaction is easily scalable and requires low concentration of supporting electrolyte and no external chemical oxidants or ligands, providing straightforward and sustainable access to 2-functionalized tetrahydroisoquinolines.
Topics & Concepts
ChemistryCatalysisMicroreactorContinuous flowCopperRelayCoupling (piping)Combinatorial chemistryElectrolyteMedicinal chemistryElectrodeOrganic chemistryPhysical chemistryQuantum mechanicsPhysicsMechanicsPower (physics)EngineeringMechanical engineeringCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques