Design, synthesis, biological evaluation and in silico studies of novel pyrrolo[3,4-d]pyridazinone derivatives with promising anti-inflammatory and antioxidant activity
Łukasz Szczukowski, Aleksandra Redzicka, Benita Wiatrak, Edward Krzyżak, Aleksandra Marciniak, Katarzyna Gębczak, Tomasz Gębarowski, Piotr Świątek
Topics & Concepts
ChemistryMeloxicamDocking (animal)AntioxidantCyclooxygenaseOxidative stressPharmacophoreAnti-inflammatoryStereochemistryCytotoxicityMannich baseIn silicoCombinatorial chemistryBiochemistryEnzymePharmacologyIn vitroOrganic chemistryGeneMedicineNursingChemical synthesis and pharmacological studiesSynthesis and Biological EvaluationSynthesis and biological activity