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Synthesis and bioevaluation of N-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-amines as tubulin polymerization inhibitors with anti-angiogenic effects

Shu-Yi Hao, Zhi-Yuan Qi, Shuai Wang, Xingrong Wang, Shi‐Wu Chen

2020Bioorganic & Medicinal Chemistry31 citationsDOI

Topics & Concepts

ChemistryTubulinStereochemistryAmine gas treatingMoietyDocking (animal)Tertiary amineMicrotubule polymerizationColchicineMicrotubuleBiochemistryCell biologyOrganic chemistryInternal medicineMedicineNursingBiologySynthesis and biological activityPhytochemical compounds biological activitiesCancer Mechanisms and Therapy
Synthesis and bioevaluation of N-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-amines as tubulin polymerization inhibitors with anti-angiogenic effects | Litcius