Mitochondrial GRIM-19 loss in parietal cells promotes spasmolytic polypeptide-expressing metaplasia through NLR family pyrin domain-containing 3 (NLRP3)-mediated IL-33 activation via a reactive oxygen species (ROS) -NRF2- Heme oxygenase-1(HO-1)–NF–кB axis
Xin Zeng, Meihua Yang, Tingbo Ye, Jinmei Feng, Xiaohui Xu, Yang Hua-an, Xin Wang, Liming Bao, Rui Li, Bingqian Xue, Jinbao Zang, Yi Huang
Topics & Concepts
Pyrin domainBiologyReactive oxygen speciesCancer researchPathogenesisMetaplasiaCell biologyInflammasomeImmunologyInflammationMedicinePathologyIL-33, ST2, and ILC PathwaysHelicobacter pylori-related gastroenterology studiesEosinophilic Esophagitis