Visible-Light-Induced Deoxygenation/Defluorination Protocol for Synthesis of γ,γ-Difluoroallylic Ketones
Yuanqiang Guo, Ruiguo Wang, Hongjian Song, Yuxiu Liu, Qingmin Wang
Abstract
Herein, we describe an efficient, practical photocatalytic deoxygenation/defluorination protocol for the synthesis of γ,γ-difluoroallylic ketones from commercially available aromatic carboxylic acids, triphenylphosphine, and α-trifluoromethyl alkenes. The protocol has good functional group tolerance and a broad substrate scope. Using this method, we accomplished the late-stage functionalization of several bioactive molecules.
Topics & Concepts
DeoxygenationChemistryTrifluoromethylSubstrate (aquarium)Functional groupTriphenylphosphineCombinatorial chemistryPhotocatalysisSurface modificationProtocol (science)Organic chemistryCatalysisMedicinePathologyAlkylOceanographyGeologyPhysical chemistryAlternative medicinePolymerFluorine in Organic ChemistryChemical Synthesis and AnalysisRadical Photochemical Reactions