A copper–platinum nanoplatform for synergistic photothermal and chemodynamic tumor therapy <i>via</i> ROS outburst and GSH exhaustion
Chao Li, Wenqing Jia, Zichao Guo, Yan Kang, Chaohui Zhou, Ren Zhao, Xi Cheng, Nengqin Jia
Abstract
a Fenton-like reaction can improve the peroxidase-like property of Cu-HCF-HA@Pt. After the probe is targeted to the tumor site, irradiation by an 808 nm near-infrared laser causes local heating and brings about photothermal tumor apoptosis when reaching 45 °C. The prepared Cu-HCF-HA@Pt combines nanozyme-catalyzed therapy with photothermal therapy to induce apoptosis in tumor cells.
Topics & Concepts
Photothermal therapyCopperCancer researchPlatinumGlutathioneReactive oxygen speciesChemistryMaterials scienceNanotechnologyMedicineBiochemistryMetallurgyCatalysisEnzymeNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisGold and Silver Nanoparticles Synthesis and Applications