Gaseous signal molecule SO<sub>2</sub> regulates autophagy through PI3K/AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with type II diabetes
Junxiong Zhao, Qian Wu, Ting Yang, Liangui Nie, Shengquan Liu, Jia Zhou, Jian Chen, Zhentao Jiang, Ting Xiao, Jun Yang, Chun Chu
Abstract
can inhibit the PI3K/AKT pathway to promote cytoprotective autophagy and inhibit cardiomyocyte apoptosis to improve myocardial fibrosis in diabetic rats. The results of this study are expected to provide new targets and intervention strategies for the prevention and treatment of diabetic cardiomyopathy.
Topics & Concepts
Diabetic cardiomyopathyMyocardial fibrosisPI3K/AKT/mTOR pathwayAutophagyProtein kinase BTUNEL assayApoptosisFibrosisMedicineSignal transductionCardiac fibrosisCell biologyInternal medicineChemistryCancer researchCardiomyopathyBiologyHeart failureBiochemistryCardiovascular Function and Risk FactorsCardiovascular Disease and AdiposityCardiac Fibrosis and Remodeling