The ruthenium complex assists in nuclear targeting and selective killing of tumor cells
Yu Lu, Di Zhu, Liujia Chan, Bo Hu, MarMar Tuohan, Li Li, Wei Wang, Yuji Wang
Abstract
NBD-Ru has dual antitumor and antimetastatic activities. Its self-assembly ability and the binding ability to transferrin assist in nuclear targeting and selective killing of tumor cells. It could realize DNA binding, thus causing cell cycle arrest.
Topics & Concepts
RutheniumTransferrinDNAChemistryCell biologyTumor cellsNuclear transportCancer researchBiophysicsCombinatorial chemistryBiochemistryCell nucleusBiologyGeneCatalysisMetal complexes synthesis and propertiesFerrocene Chemistry and ApplicationsClick Chemistry and Applications