NLRX1 knockout aggravates lipopolysaccharide (LPS)-induced heart injury and attenuates the anti-LPS cardioprotective effect of CYP2J2/11,12-EET by enhancing activation of NF-κB and NLRP3 inflammasome
Gang Zhao, Xiaoting Wang, Sabrina Edwards, Meiyan Dai, Jianfeng Li, Lujin Wu, Rongfu Xu, Jinxiang Han, Haitao Yuan
Topics & Concepts
InflammasomeLipopolysaccharideChemistryReactive oxygen speciesKnockout mouseMitochondrial ROSProinflammatory cytokineCell biologyNF-κBInflammationPharmacologySignal transductionImmunologyBiochemistryBiologyReceptorEicosanoids and Hypertension PharmacologyPeroxisome Proliferator-Activated ReceptorsInflammatory mediators and NSAID effects