Litcius/Paper detail

Sibling Comparisons to Account for Confounding in Observational Studies

Viktor H. Ahlqvist, Brian Lee, Yu-Han Chiu

2026JAMA10 citationsDOI

Abstract

This JAMA Guide to Statistics and Methods explains how sibling analysis can be used to account for confounding in observational studies, using the example of a study on acid suppressants during pregnancy and risk of neuropsychiatric disorders in offspring.

Topics & Concepts

MedicineObservational studyConfoundingSiblingPregnancyMEDLINEDemographyPediatricsCohort studyEpidemiologyResearch designOffspringMeta-analysisPsychiatryPrenatal Substance Exposure EffectsAdvanced Causal Inference TechniquesNeonatal and fetal brain pathology