Therapy and diagnosis of Alzheimer's disease: from discrete metal complexes to metal–organic frameworks
Amalia García-García, Sara Rojas, Antonio Rodríguez‐Diéguez
Abstract
). This review discusses the recent progress in the development of novel discrete metal complexes and metal-organic frameworks (MOFs) for the treatment, diagnosis and theragnosis of AD. These advanced therapies for AD treatment are organized according to the target: Aβ peptides, hyperphosphorylated tau proteins, synaptic dysfunction, and mitochondrial failure with subsequent oxidative stress.
Topics & Concepts
Oxidative stressDiseaseContext (archaeology)NeuroscienceBiocompatibilityAmyloid (mycology)HyperphosphorylationMedicineNanotechnologyChemistryPathologyPsychologyMaterials scienceBiologyInternal medicineBiochemistryOrganic chemistryPaleontologyKinaseAlzheimer's disease research and treatmentsMetal-Organic Frameworks: Synthesis and ApplicationsNanocluster Synthesis and Applications