Activity of β-Lactam Antibiotics against Metallo-β-Lactamase-Producing <i>Enterobacterales</i> in Animal Infection Models: a Current State of Affairs
Tomefa E. Asempa, Kamilia Abdelraouf, David P. Nicolau
Abstract
Metallo-β-lactamases (MBLs) result in resistance to nearly all β-lactam antimicrobial agents, as determined by currently employed susceptibility testing methods. However, recently reported data demonstrate that variable and supraphysiologic zinc concentrations in conventional susceptibility testing media compared with physiologic (bioactive) zinc concentrations may be mediating discordant in vitro - in vivo MBL resistance.
Topics & Concepts
MicrobiologyAntibioticsLactamIn vivoAntimicrobialIn vitroAntibiotic resistanceBiologyChemistryBiochemistryBiotechnologyStereochemistryAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyAntibiotic Use and Resistance