Metformin rescues Parkin protein expression and mitophagy in high glucose-challenged human renal epithelial cells by inhibiting NF-κB via PP2A activation
Yulan Zhao, Mingjin Sun
Topics & Concepts
MitophagyParkinGene knockdownATF4MitochondrionViability assayCell biologyBiologyApoptosisAutophagyPINK1Molecular biologyCancer researchChemistryInternal medicineUnfolded protein responseMedicineBiochemistryDiseaseParkinson's diseaseAutophagy in Disease and TherapyMetabolism, Diabetes, and CancerParkinson's Disease Mechanisms and Treatments