Interleukin-2-secreting T helper cells promote extra-follicular B cell maturation via intrinsic regulation of a B cell mTOR-AKT-Blimp-1 axis
Caterina E. Faliti, Maria Mesina, Jinyong Choi, Simon Bélanger, Monique Marshall, Christopher M. Tipton, Sakeenah L. Hicks, Prashanti Chappa, Maria A. Cardenas, Mohamed S. Abdel-Hakeem, Theresa C. Thinnes, Christopher A. Cottrell, Christopher D. Scharer, William R. Schief, David Nemazee, Matthew C. Woodruff, John M. Lindner, Igñacio Sanz, Shane Crotty
Topics & Concepts
BiologyPI3K/AKT/mTOR pathwayB cellCell biologyProtein kinase BFollicular phaseCellInterleukin 4ImmunologyCancer researchSignal transductionCytokineEndocrinologyGeneticsAntibodyImmune Cell Function and InteractionT-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers