Chronic intermittent hypoxia promotes early intrahepatic endothelial impairment in rats with nonalcoholic fatty liver disease
Alberto Hernández‐Bustabad, Dalia Morales‐Arráez, Francisco Javier González-Paredes, Beatriz Abrante, Felícitas Díaz-Flores, Pedro Abreu-González, Raquel de la Barreda, Enrique Quintero, Manuel Hernández‐Guerra
Abstract
We believe the findings are of relevance because we demonstrate that chronic intermittent hypoxia further augments impaired hepatic endothelial dysfunction in nonalcoholic fatty liver disease rats. Because obstructive sleep apnea syndrome is associated with systemic endothelial dysfunction in cardiovascular disorders, and chronic intermittent hypoxia is an independent and reversible risk factor for hypertension and coronary artery disease, we hypothesized that this entity may be of potential relevance in the pathophysiology of nonalcoholic fatty liver disease.