Nox4-mediated ROS production is involved, but not essential for TGFβ-induced lens EMT leading to cataract
Shannon Das, Tayler F.L. Wishart, Karin Jandeleit‐Dahm, Frank J. Lovicu
Topics & Concepts
NOX4Downregulation and upregulationNADPH oxidaseEpithelial–mesenchymal transitionLens (geology)Transforming growth factorCell biologyCataractsBiologyTransdifferentiationCancer researchChemistryReactive oxygen speciesBiochemistryGeneStem cellGeneticsPaleontologyNeutrophil, Myeloperoxidase and Oxidative MechanismsConnexins and lens biologyNitric Oxide and Endothelin Effects