Novel pyrrolidine-2,4-dione derivatives containing pharmacophores of both hydrazine and diphenyl ether as potential antifungal agents: design, synthesis, biological evaluation, and 3D-QSAR study
Haoran Hu, An Wang, Lingling Qiu, Xiaobin Wang, Min Chen, Ai‐Min Lu, Chun‐Long Yang
Abstract
Novel pyrrolidine-2,4-dione derivatives were designed based on natural products. Some synthesized compounds showed excellent antifungal activity. Scanning electron microscopy was used to observe mycelium morphology. 3D-QSAR was also studied.
Topics & Concepts
ChemistryPyrrolidinePharmacophoreAntifungalDiphenyl etherQuantitative structure–activity relationshipEtherOrganic chemistryCombinatorial chemistryStereochemistryDermatologyMedicinePlant Pathogens and Fungal DiseasesPlant-Microbe Interactions and ImmunityFungal Plant Pathogen Control