Human Serum Albumin-Inspired Glycopeptide-Based Multifunctional Inhibitor of Amyloid-β Toxicity
Rajsekhar Roy, Krishnangsu Pradhan, Juhee Khan, Gaurav Das, Nabanita Mukherjee, Durba Das, Surajit Ghosh
Abstract
-mediated toxicity by reducing intracellular ROS generation and stabilizing the mitochondrial membrane potential. All these exciting features show Glupep to be a potent inhibitor of Aβ42-mediated multifaceted toxicity and a prospective therapeutic lead for AD.
Topics & Concepts
TetrapeptideChemistryNeurotoxicityReactive oxygen speciesPeptideToxicityBiochemistryAmyloid (mycology)ChelationBiophysicsBiologyInorganic chemistryOrganic chemistryAlzheimer's disease research and treatmentsCholinesterase and Neurodegenerative DiseasesProtein Structure and Dynamics