Recent synthetic strategies for the functionalization of fused bicyclic heteroaromatics using organo-Li, -Mg and -Zn reagents
V. Dhayalan, Vishal S. Dodke, Marappan Pradeep Kumar, Hatice Seher Korkmaz, Anja Hoffmann‐Röder, P. Amaladass, Rambabu Dandela, Ragupathy Dhanusuraman, Paul Knochel
Abstract
) cross-coupling reactions with fused heteroaryl halides. In addition, the use of some transition metal-catalyzed processes occasionally allows a reversed role of the reactants in cross-coupling reactions, providing alternative synthetic routes for the preparation of fused heteroaromatic-based bioactive drugs and natural products. In line with this, this article points to novel methods for the functionalization of bicyclic heteroaromatic scaffolds by organometallic reagents that have been published in the period 2010-2023.
Topics & Concepts
ReagentSurface modificationBicyclic moleculeChemistryCombinatorial chemistryOrganic chemistryPhysical chemistryCoordination Chemistry and OrganometallicsSynthesis and Biological EvaluationAsymmetric Synthesis and Catalysis