Risk factors of epilepsy secondary to viral encephalitis: A meta-analysis
Qian Yang, Wei Ben
Abstract
OBJECTIVE: To systematically evaluate the risk factors of post-encephalitis epilepsy (PEE). METHODS: Systematic computerized searches of databases such as Cochrane Library, PubMed and EMBASE were performed. The meta-analysis of pooled odds ratios and 95% confidence intervals for PEE risk were calculated. RESULTS: Sixteen studies with 2504 patients were included for meta-analysis. The results showed that PEE was associated with coma, seizure, status epilepticus, cranial MRI abnormality, focal EEG abnormality, and positive herpes simplex virus (HSV) in cerebrospinal fluid (CSF). CONCLUSION: Coma, seizures or status epilepticus, abnormal MRI and focal EEG, and HSV in CSF were the risk factors of PEE.
Topics & Concepts
Status epilepticusMeta-analysisOdds ratioComa (optics)MedicineEncephalitisHerpes simplex virusCochrane LibraryViral encephalitisAbnormalityEpilepsyConfidence intervalElectroencephalographyAnesthesiaInternal medicineVirusVirologyPsychiatryPhysicsOpticsInfectious Encephalopathies and EncephalitisEpilepsy research and treatmentAutoimmune Neurological Disorders and Treatments