Deep representation learning determines drug mechanism of action from cell painting images
Daniel R. Wong, David J. Logan, Santosh Hariharan, Robert V. Stanton, Djork-Arné Clevert, Andrew Kiruluta
Abstract
Fluorescent-based microscopy screens carry a broad range of phenotypic information about how compounds affect cellular biology.
Topics & Concepts
Representation (politics)Mechanism (biology)Mechanism of actionArtificial intelligenceFluorescence microscopeComputer scienceAction (physics)Drug actionDrugFluorescenceBiophysicsComputational biologyCell biologyChemistryBiologyIn vitroPhysicsBiochemistryOpticsPharmacologyPoliticsPolitical scienceLawQuantum mechanicsCell Image Analysis TechniquesImage Processing Techniques and ApplicationsSingle-cell and spatial transcriptomics