Engineering biology for sustainable 1,4-butanediol synthesis
Connor L. Trotter, Gautham S. Babu, Stephen Wallace
Abstract
Over the past decade, numerous approaches have been taken to replace unsustainable chemical syntheses with green biosynthetic alternatives. In a landmark paper, Yim et al. utilised an in silico-to-in vivo workflow to enable the high-level bioproduction of the unnatural small molecule 1,4-butanediol in the bacterium Escherichia coli.
Topics & Concepts
BioproductionSynthetic biology2,3-ButanediolIn silicoEscherichia coliWorkflowComputational biologyMetabolic engineeringChemistry1,4-ButanediolChemical spaceBiologyBiotechnologyBiochemical engineeringBiochemistryCombinatorial chemistryComputer scienceDrug discoveryEngineeringDatabaseFermentationEnzymeGeneCatalysisMicrobial Metabolic Engineering and BioproductionEnzyme Catalysis and ImmobilizationBiochemical Acid Research Studies