Recent Progress on the Mild Deprotection of Dithioketals, Dithioacetals, and Oxathiolanes
Jun Yan, Jean‐Luc Pozzo, Abdallah Hamzé, Olivier Provot
Abstract
Abstract Reactions for the deprotection of carbonyl derivatives have been of considerable interest to the scientific community. In recent years efforts have been made to develop mild, experimentally simple, and environmentally friendly methods. This update to previous research provides a comprehensive review of processes for the deprotection of thioacetals, thioketals and oxathiolanes to the corresponding carbonyl compounds which have been published since 2006. The main approaches used iodonium or bromonium ions, oxidants, photocatalysis, metal salts or, slightly acidic hydrolysis conditions. For each protocol, representative examples will illustrate the scope of the process and its tolerance towards functional groups.