Hyposplenism and Gastrointestinal Diseases: Significance and Mechanisms
Abhinav Mathur, Mairi H McLean, Huan Cao, Mark A. Vickers
Abstract
BACKGROUND: Functional hyposplenism is a recognized complication of several gastroenterological disorders, including coeliac and inflammatory bowel diseases, and is believed to contribute to the increased infection risk seen in these disorders. SUMMARY: The mechanisms of hyposplenism are poorly understood. In this article, we review possible mechanisms underlying development of functional hyposplenism and discuss implications for its management. KEY MESSAGES: Identifying functional hyposplenism is important, as it may permit earlier recognition and treatment of serious infections through patient education and vaccination.
Topics & Concepts
MedicineGastroenterologyClinical significanceInternal medicineGastrointestinal disorders and treatmentsAbdominal Trauma and InjuriesDiverticular Disease and Complications