Mononuclear ruthenium(<scp>ii</scp>) theranostic complexes that function as broad-spectrum antimicrobials in therapeutically resistant pathogens through interaction with DNA
Kirsty L. Smitten, Eleanor J. Thick, Hannah M. Southam, Jorge Bernardino de la Serna, Simon J. Foster, Jim A. Thomas
Abstract
A mononuclear ruthenium(<sc>ii</sc>) complex based of the tpphz ligand is shown to be a broad-band antimicrobial theranostic active against a range of AMR pathogens.
Topics & Concepts
RutheniumAntimicrobialBroad spectrumChemistryLigand (biochemistry)Peripheral blood mononuclear cellCombinatorial chemistryFunction (biology)DNABroad bandIn vitroBiologyBiochemistryOrganic chemistryReceptorCell biologyPhysicsCatalysisOpticsMetal complexes synthesis and propertiesSynthesis and Biological EvaluationPneumocystis jirovecii pneumonia detection and treatment