Metabolic alterations in plasma from patients with familial and idiopathic Parkinson’s disease
Sokhna M. S. Yakhine-Diop, José Á. Morales-García, Mireia Niso‐Santano, Rosa A. González‐Polo, Elisabet Uribe-Carretero, Guadalupe Martínez-Chacón, Sylvère Durand, Maria Chiara Maiuri, Ana Aiastui, Miren Zulaica, Javier Ruiz‐Martínez, Adolfo López de Munaín, Jordi Pérez‐Tur, Ana Pérez‐Castillo, Guido Kroemer, José Manuel Bravo‐San Pedro, José M. Fuentes
Abstract
gene) Parkinson's disease, as well as, from mice treated with 6-hydroxydopamine to induce Parkinson disease. Both human and murine Parkinson was accompanied by an increase in plasma levels of unconjugated bile acids (cholic acid, deoxycholic acid and lithocholic acid) and purine base intermediary metabolites, in particular hypoxanthine. The comprehensive metabolomic analysis of plasma from Parkinsonian patients underscores the importance of bile acids and purine metabolism in the pathophysiology of this disease. Therefore, plasma measurements of certain metabolites related to these pathways might contribute to the diagnosis of Parkinson's Disease.