One-pot synthesis of 2-hydroxymethylindoles<i>via</i>photoredox-catalyzed ketyl–ynamide coupling/1,3-allylic alcohol transposition
Ze‐Shu Wang, Yang‐Bo Chen, Kun Wang, Zhou Xu, Long‐Wu Ye
Abstract
An efficient photoredox-catalyzed ketyl–ynamide coupling of alkyl sulfonyl substituted ynamides followed by 1,3-allylic alcohol transposition in one-pot has been developed, affording 2-hydroxymethylindoles in generally moderate to good yields.
Topics & Concepts
KetylTransposition (logic)Allylic rearrangementChemistryCatalysisAlcoholCoupling (piping)Allylic alcoholCombinatorial chemistryOrganic chemistryMaterials scienceRadicalComputer scienceMetallurgyArtificial intelligenceCatalytic Alkyne ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques