cGAMP-adjuvanted multivalent influenza mRNA vaccines induce broadly protective immunity through cutaneous vaccination in mice
Wandi S. Zhu, Lai Wei, Chunhong Dong, Ye Wang, Joo Hee Kim, Yao Ma, Gilbert X. Gonzalez, Bao‐Zhong Wang
Abstract
) T cells in lungs were observed in cGAMP mRNA LNPs immunized group. These results demonstrated that cGAMP is an effective adjuvant for cutaneous vaccination of multivalent mRNA LNP vaccines in mice to induce stronger immune responses in the spleen and lung, and the cGAMP-adjuvanted mRNA LNPs protected against homologous and heterologous viral infection.
Topics & Concepts
ImmunogenicityImmune systemVirologyMessenger RNAAdjuvantVaccinationImmunologyAntibodyBiologySpleenHeterologousImmunityAntigenImmunizationGeneBiochemistryImmunotherapy and Immune ResponsesImmune Cell Function and InteractionImmune Response and Inflammation