Current Status of COVID-19 Therapies and Drug Repositioning Applications
Özlem Altay, Elyas Mohammadi, Simon Lam, Hasan Türkez, Jan Borén, Jens Nielsen, Mathias Uhlén, Adil Mardinoğlu
Abstract
The rapid and global spread of a new human coronavirus (SARS-CoV-2) has produced an immediate urgency to discover promising targets for the treatment of COVID-19. Drug repositioning is an attractive approach that can facilitate the drug discovery process by repurposing existing pharmaceuticals to treat illnesses other than their primary indications. Here, we review current information concerning the global health issue of COVID-19 including promising approved drugs and ongoing clinical trials for prospective treatment options. In addition, we describe computational approaches to be used in drug repurposing and highlight examples of in silico studies of drug development efforts against SARS-CoV-2.