Rhodiasolv PolarClean – a greener alternative in solid-phase peptide synthesis
Ashish Kumar, Anamika Sharma, Beatriz G. de la Torre, Fernando Alberício
Abstract
PolarClean, a green solvent prepared through the valorization of a byproduct of Nylon-66 manufacturing, shows an excellent capacity to dissolve all Fmoc-amino acids and key coupling reagents and additives. It can also swell polystyrene and ChemMatrix, the two resins most widely used in solid-phase peptide synthesis. The synthesis of model peptides has been carried out, rendering the target peptide as a major component. The performance of PolarClean demonstrates its utility in the toolbox for Green Solid-Phase Peptide Synthesis.
Topics & Concepts
ChemistryPeptide synthesisPeptidePolystyreneCombinatorial chemistrySolventSolid-phase synthesisPhase (matter)ReagentRendering (computer graphics)Organic chemistryPolymerBiochemistryComputer scienceComputer graphics (images)Chemistry and Chemical EngineeringChemical Synthesis and Analysis