β-Carotene: Preventive Role for Type 2 Diabetes Mellitus and Obesity: A Review
Gabriela Marcelino, David Johane Machate, Karine de Cássia Freitas, Priscila Aiko Hiane, Iriani Rodrigues Maldonade, Arnildo Pott, Marcel Arakaki Asato, Camila Jordão Cândido, Rita de Cássia Avellaneda Guimarães
Abstract
Carotenoids are vital antioxidants for plants and animals. They protect cells from oxidative events and act against the inflammatory process and carcinogenesis. Among the most abundant carotenoids in human and foods is β-carotene. This carotenoid has the highest level of provitamin A activity, as it splits into two molecules of retinol through the actions of the cytosolic enzymes: β-carotene-15,15'-monooxygenase (β-carotene-15,15'-oxygenase 1) and β-carotene-9',10'-dioxygenase (β-carotene-9',10'-oxygenase 2). The literature supports the idea that β-carotene acts against type 2 diabetes mellitus, cardiovascular diseases, obesity, and metabolic syndrome. Due to the many processes involved in β-carotene biosynthesis and metabolic function, little is known about such components, since many mechanisms have not yet been fully elucidated. Therefore, our study concisely described the relationships between the consumption of carotenoids, with emphasis on β-carotene, and obesity and type 2 diabetes mellitus and its associated parameters in order to understand the preventive role of carotenoids better and encourage their consumption.