Cysteine-responsive prodrug of the anti-cancer drug amonafide: fluorogenic adjuvant drug delivery with hydrogen sulfide (H<sub>2</sub>S)
Sulendar K. Mahato, Pallavi Barman, Md. Badirujjaman, Krishna P. Bhabak
Abstract
l -Cysteine (Cys)-responsive turn-on fluorogenic prodrug AM-ITC was developed for the adjuvant delivery of the anti-cancer drug amonafide and the gasotransmitter hydrogen sulfide (H 2 S).
Topics & Concepts
ProdrugChemistryDrugDrug deliveryCysteineAdjuvantPharmacologyTargeted drug deliveryCombinatorial chemistryHydrogen sulfideBiochemistryEnzymeMedicineOrganic chemistryImmunologySulfurSulfur Compounds in BiologyAmino Acid Enzymes and MetabolismFibroblast Growth Factor Research