N-Heterocyclic carbene catalyzed asymmetric [3 + 3] cycloaddtion of β,β-disubstituted, α,β-unsaturated carboxylic esters with 3-aminobenzofurans
Chonglong He, Yipeng Zhou, Zhanhuan Li, Jianfeng Xu, Xingkuan Chen
Abstract
An NHC-catalyzed β-carbon functionalization reaction to afford enantioenriched benzofuran fused δ-lactams bearing an all-carbon quaternary stereocenter is documented.
Topics & Concepts
ChemistryStereocenterCarbeneBenzofuranCatalysisSurface modificationCarbon fibersOrganic chemistryQuaternary carbonEnantioselective synthesisMedicinal chemistryPhysical chemistryMaterials scienceComposite numberComposite materialN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling ReactionsSynthetic Organic Chemistry Methods