CuI/2-Aminopyridine 1-Oxide Catalyzed Amination of Aryl Chlorides with Aliphatic Amines
Wenjie Liu, Jiamin Xu, Xiahong Chen, Fu-Xing Zhang, Zhifeng Xu, Deping Wang, Yongqiang He, Xiaohong Xia, Xin Zhang, Yun Liang
Abstract
A class of 2-aminopyridine 1-oxides are discovered to be effective ligands for the Cu-catalyzed amination of less reactive (hetero)aryl chlorides. A wide range of functionalized (hetero)aryl chlorides reacted with various aliphatic amines to afford the desired products in good to excellent yields under the catalyst of CuI/2-aminopyridine 1-oxides. Furthermore, the catalyst system worked well for the coupling of cyclic secondary amines and N-methyl benzylamine with (hetero)aryl chlorides.
Topics & Concepts
ChemistryAminationCatalysisArylBenzylamine2-AminopyridineOrganic chemistryOxideCombinatorial chemistryPolymer chemistryAlkylCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions