Exercise training and BDNF injections alter amyloid precursor protein (APP) processing enzymes and improve cognition
Bradley J. Baranowski, Ahmad Mohammad, Michael S. Finch, Alex Brown, Roopan Dhaliwal, Daniel M. Marko, Paul J. LeBlanc, Cheryl M. McCormick, Val A. Fajardo, Rebecca E. K. MacPherson
Abstract
Our study presents the novel findings that chronic peripheral BDNF injections result in regulation of APP processing enzymes and improved cognition to a similar extent as exercise training. These findings highlight the potential efficacy of using BDNF as a therapeutic intervention in the prevention of neurodegenerative diseases (i.e., Alzheimer's disease). Furthermore, future evidence-based preventative or therapeutic interventions that increase BDNF and reduce BACE1 will be of value for populations that are at risk of AD.
Topics & Concepts
Amyloid precursor proteinCognitionCognitive trainingMedicineAlzheimer's diseaseBrain-derived neurotrophic factorDiseasePhysical exerciseNeurosciencePsychologyNeurotrophic factorsBioinformaticsPhysical therapyInternal medicineBiologyReceptorNerve injury and regenerationAlzheimer's disease research and treatmentsAutism Spectrum Disorder Research