N<sub>2</sub>Phos – an easily made, highly effective ligand designed for ppm level Pd-catalyzed Suzuki–Miyaura cross couplings in water
Nnamdi Akporji, Ruchita R. Thakore, Margery Cortes‐Clerget, Joel Andersen, Evan B. Landstrom, Donald H. Aue, Fabrice Gallou, Bruce H. Lipshutz
Abstract
A new, biaryl phosphine-containing ligand, N<sub>2</sub>Phos, forms a 1 : 1 complex with Pd resulting in an active catalyst at the ppm level for Suzuki–Miyaura couplings in water, enabled by an aqueous micellar medium. Notably, aryl chlorides are shown to be amenable substrates.
Topics & Concepts
PhosPhosphineLigand (biochemistry)CatalysisArylChemistryAqueous solutionAqueous mediumCombinatorial chemistryOrganic chemistryReceptorAlkylBiochemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsChemical synthesis and alkaloids