Electrochemical chemoselective hydroxyl group transformation: anthranilic acyl modification of tyrosine bioconjugations
Shiqi You, Ruitao Wang, Chao Ma, Cuifen Lu, Guichun Yang, Li Liu, Yue Weng, Meng Gao
Abstract
We report an electrochemically promoted transformation for accessing tyrosine-containing biomolecules with anthranilic acid derivatives. Utilizing TBAF as the hydrogen-bonding additive, the tyrosine residue can be well labelled under mild conditions.
Topics & Concepts
ChemistryAnthranilic acidTyrosineResidue (chemistry)ElectrochemistryCombinatorial chemistryHydrogen bondTransformation (genetics)Organic chemistryStereochemistryBiochemistryMoleculePhysical chemistryElectrodeGeneChemical Synthesis and AnalysisClick Chemistry and ApplicationsRadical Photochemical Reactions