Histone Deacetylases 1 and 2 in Memory Function
Ping‐Chieh Pao, Li‐Huei Tsai
Abstract
Histone deacetylases (HDACs) have been implicated in learning and memory, and their dysregulation has been linked to cognitive impairment in brain aging and neurodegenerative diseases. In this review, we focus on HDAC1 and HDAC2, highlighting recent progress on their roles in regulating brain function through distinct mechanisms, including gene repression and DNA repair pathways. Moreover, we discuss evidence demonstrating how HDAC1 and HDAC2 could be modulated and their potential as targets to combat memory deficits.
Topics & Concepts
HistoneNeuroscienceHDAC1Histone deacetylase 2Histone deacetylaseBiologyMemory impairmentCognitionDNA repairGeneGeneticsHistone Deacetylase Inhibitors ResearchGenetics and Neurodevelopmental DisordersEpigenetics and DNA Methylation