Tumor cell senescence-induced macrophage CD73 expression is a critical metabolic immune checkpoint in the aging tumor microenvironment
Yue Deng, Qingyan Chen, Xiao Yang, Yajie Sun, Bin Zhang, Wenwen Wei, Suke Deng, Jingshu Meng, Yan Hu, Yijun Wang, Zhanjie Zhang, Lu Wen, Fang Huang, Chao Wan, Kunyu Yang
Abstract
TAMs expressed CD73 contributes significantly to the adenosine accumulation in the senescent TME, suggesting targeting CD73 is a novel synergistic anti-tumor strategy in the aging microenvironment.
Topics & Concepts
Tumor microenvironmentSenescenceCancer researchImmune systemBiologyTranscriptomeImmune checkpointMass cytometryInflammationDownregulation and upregulationCellFlow cytometryImmunotherapyCell biologyImmunologyGene expressionPhenotypeGeneGeneticsBiochemistryImmune cells in cancerNanoplatforms for cancer theranosticsEpigenetics and DNA Methylation