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Neoadjuvant chemoradiation with or without PD-1 blockade in locally advanced rectal cancer: a randomized phase 2 trial

Yingchi Yang, Kai Pang, Guole Lin, Xinzhi Liu, Jiale Gao, Jiaolin Zhou, Lai Xu, Zhidong Gao, Yingchao Wu, Ang Li, Jiagang Han, Guoju Wu, Xin Wang, Fei Li, Yingjiang Ye, Jie Zhang, Guangyong Chen, Hao Wang, Yuanyuan Kong, Aiwen Wu, Yi Xiao, Hongwei Yao, Zhongtao Zhang

2025Nature Medicine31 citationsDOI

Topics & Concepts

MedicineClinical endpointColorectal cancerInternal medicineOncologyRandomized controlled trialNeoadjuvant therapyConfidence intervalAdverse effectRadiation therapyBlockadeHazard ratioImmune checkpointCancerSurgeryImmunotherapyBreast cancerReceptorColorectal Cancer Surgical TreatmentsColorectal and Anal CarcinomasColorectal Cancer Treatments and Studies
Neoadjuvant chemoradiation with or without PD-1 blockade in locally advanced rectal cancer: a randomized phase 2 trial | Litcius