Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis
Nur Yucer, Rodney Ahdoot, Michael J. Workman, Alex Laperle, María Sol Recouvreux, Kathleen Kurowski, Diana J. Naboulsi, Victoria Liang, Ying Qu, Jasmine Plummer, Simon A. Gayther, Sandra Oršulić, Beth Y. Karlan, Clive N. Svendsen
Abstract
Germline pathogenic mutations in BReast CAncer (BRCA1) genes are thought to drive normal fallopian tube epithelial (FTE) cell transformation to high-grade serous ovarian cancer. No human models capture the sequence of events for disease initiation and progression. Here, we
Topics & Concepts
OrganoidBiologyCarcinogenesisInduced pluripotent stem cellOvarian cancerGermlineCancer researchGermline mutationCancerTransplantationSerous fluidMutationGeneticsInternal medicineGeneMedicineEmbryonic stem cellBiochemistryCRISPR and Genetic EngineeringMicrotubule and mitosis dynamicsOvarian cancer diagnosis and treatment