Immune checkpoint inhibitors
Guido Kroemer, Laurence Zitvogel
Abstract
Three papers by James Allison and Tasuku Honjo published in JEM between 1995 and 2000 crystallized seminal insights into the role of CTLA-4 and PD-1 in immunosuppression (Krummel and Allison. 1995. J. Exp. Med.https://doi.org/10.1084/jem.182.2.459; van Elsas et al. 1999. J. Exp. Med.https://doi.org/10.1084/jem.190.3.355; Freeman et al. 2000. J. Exp. Med.https://doi.org/10.1084/jem.192.7.1027). These papers laid the basis for modern cancer immunotherapy and led to a shared 2018 Nobel Prize.
Topics & Concepts
ImmunosuppressionImmunotherapyImmune systemCancer immunotherapyImmune checkpointMedicineImmunologyCancer Immunotherapy and BiomarkersImmunotherapy and Immune ResponsesCancer, Stress, Anesthesia, and Immune Response